半乳糖凝集素-3、同型半胱氨酸与超敏C反应蛋白与心房颤动左心房结构重构关系的探讨.pdfVIP

摘要 2 2 (35.48±7.20ml/m )及对照组(31.39±4.51ml/m ) (P ＜0.05)，且阵发性房颤组大于对 照组(P ＜0.05) ；Pearson 相关性分析显示：左心房容积指数与半乳糖凝集素-3 (r=0.618, P ＜0.01)、超敏C 反应蛋白(r=0.602, P ＜0.01)、同型半胱氨酸(r=0.348, P ＜0.01)呈正相关。多元线性回归分析结果显示：左心房容积指数与左房内径、 血清半乳糖凝集素-3 水平、外周血超敏C 反应蛋白水平以及心房颤动呈线性相 关； 3、多因素Logistic 回归分析结果显示：半乳糖凝集素-3、超敏C 反应蛋白、 年龄及左心房容积指数是心房颤动的发生的危险因素。 结论： 1、持续性及阵发性房颤患者半乳糖凝集素-3、同型半胱氨酸及超敏C 反应 蛋白水平均高于窦性心律者，且持续性房颤高于阵发性房颤； 2 、房颤患者半乳糖凝集素-3 及超敏C 反应蛋白与左心房容积指数呈线性相 关，提示心房纤维化及炎症反应参与了左心房结构重构，在房颤的发生、发展 与维持过程中起重要作用； 3、房颤患者同型半胱氨酸与左心房容积指数呈正相关，氧化应激可能参与 了左心房结构重构。 关键词：心房颤动；心房结构重构；心肌纤维化；炎症反应；氧化应激；左心 房容积指数 III Abstract ABSTRACT Objective: In this study, we investigate that the role of galactoselectin-3(Galectin-3), high sensitive C-reactive protein(hs-CRP) and homo cysteine (HCY) play in atrial structural remodeling via their correlation with left atrial volume index(LAVI). To promote better understanding of pathogenesis and risk factors of atrial fibrillation, provide more ideas for the prevention and treatment of atrial fibrillation in clinic. Methods: We included 107 AF patients(51 male and 56 female, mean age 65.2 ±8.6) from the second affiliated hospital of Nanchang university between Sep,2013 and Sep,2014, including 61 persistent AF and 46 paroxysmal AF. At the same time, 40 sinus rhythm( basic date similar to the AF group )were included as controls. Baseline characteristics were recorded. Fasting blood were siphoned in the second morning to detect serum levels of hepatorenal function, glucose, blood lipid, thyroid function, BNP, etc. All patients underwent electrocardiogram and 24 hour