格列本脲和二甲双胍复方制剂治疗2型糖尿病疗效观察.docVIP

格列本脲和二甲双胍复方制剂治疗2型糖尿病疗效观察 　　[摘要]目的：探讨格列本脲和二甲双胍复方制剂治疗2型糖尿病患者对糖化血红蛋白(GHbA1c)、空腹血糖(FPG)以及标准餐后2 h血糖(2hPG)的影响。方法：把口服降糖药控制血糖效果不佳的患者86例随机分成治疗组、对照组,治疗观察12周，比较治疗组和对照组的疗效。结果：治疗组显效的病例有32例(71.11％)、总有效率为95.55%，对照组显效的病例有23例(56.10％)、总有效率为80.49%；两组比较具有显著性差异(P<0.05)，说明格列本脲和盐酸二甲双胍复合片疗效优于达美康。结论：格列本脲和盐酸二甲双胍可以相互补充，协同发挥作用，从而改善2型糖尿病患者的代谢缺陷，最终改善人体对血糖的控制。该制剂尤其对单纯使用盐酸二甲双胍或格列本脲再次治疗无效的患者，具有良好的效果。 　　[关键词]格列本脲；二甲双胍；2型糖尿病；疗效 　　[中图分类号]R587[文献标识码]B [文章编号]1673-7210（2007）10（c）-033-02 　　 　　Effects of Metformin combining with Glibenclamide in type 2 diabetes mellitus 　　XIAO Qi-mei 　　(The Third People's Hosipital of Hengyang,Hengyang 421005,China) 　　[Abstract]Objective：To investigate whether Metformin combined with Glibenclamide can reduce GHbA1c、FPG and 2hPG in type 2 diabetes mellitus(T2DM) by comparing two groups. Methods：86 T2DM patients who had got negtive effect by using oral hypoglycemic agents were randomly divided into two groups. One of them was therapeutic group by using Ｍetformin combining with Ｇlibenclamide. And another was control group by using diamicron. Results:In therapeutic group,there were 32(71.11%)excellent cases,and total effective rate was 95.55%. In control group there were 23(56.10%)excellent cases, and total effective rate was 80.49%. Two groups had significant difference (P<0.05) in these items. It showed that Metformin combined with Glibenclamide had advantage to diamicron in curative effect. Conclusion:Metformin and glibenclamide can supply each other, and produce curative effect synergistically. They can improve metabolic defect in type 2 diabetes mellitus and reduce blood glucose of human. Metformin combined with Glibenclamide has good effect to patients who did not get curative effect by treating them with Metformin or Glibenclamide. 　　[Key words]Glibenclamide；Metformin；Type 2 diabetes mellitus；Curative effect 　　 　　在2型糖尿病的治疗中，常常需要联用两种或多种降糖药。为了满足临床需要，美国施贵宝公司开发了格列本脲和盐酸二甲双胍复合片(商品名Glucovance)，并于2000年7月31日获美国FDA批准上市。为进一步观察其对2型糖尿病患者的治疗作用，笔者从2005年10月~2007年5月，用格列本脲和盐酸