根除治疗幽门螺杆菌感染对小儿缺铁性贫血疗效影响.docVIP

根除治疗幽门螺杆菌感染对小儿缺铁性贫血疗效影响 　　[摘要] 目的：探讨幽门螺杆菌（Hp）感染与缺铁性贫血(IDA)的关系以及根除治疗的意义。方法：确诊IDA合并Hp感染患儿56例，随机分为治疗组(28例)和对照组(28例)，分别进行铁剂治疗加抗Hp感染治疗和单纯的铁剂治疗，分析开始治疗6周后、随访1年后的疗效。结果：开始治疗6周后，根除治疗组患儿的血清铁蛋白(SF)水平为（38.14±18.43） g/L，显著高于对照组患儿(P<0.05)；随访1年，原根除治疗组患儿SF水平达到（39.18±15.92） g/L，显著高于原对照组患儿的(22.13±12.94） g/L，Hb、MCV、MCH三项指标也显著高于对照组，差异有统计学意义(P<0.01，P<0.05)；治疗过程中均未发现严重副作用。结论：Hp感染与IDA关系密切，根除Hp感染可明显提高IDA的疗效，对Hp阳性的IDA患儿应同时Hp根除治疗。 　　[关键词] 缺铁性贫血；幽门螺杆菌感染；根除 　　[中图分类号] R725.5[文献标识码]A[文章编号]1673-7210（2009）06（c）-035－０2 　　 　　Influence of radical treatment of Helicobacter pylori infection on iron deficiency anemia in children curative effect 　　LI Wenxiu 　　(Department of Pediatric,Guanlan People′s Hospital of Shenzhen City, Guangdong Province, Shenzhen518110,China) 　　[Abstract] Objective: To investigate the relationship between Helicobacter pylori(Hp) infection and iron deficiency anemia (IDA) and the significance of radical treatment. Methods: Confirmed 56 cases of children with IDA merge Hp infection, were randomly divided into treatment group(28 cases) and control group(28 cases), respectively to iron therapy plus anti-Hp infection treatment and simple iron treatment, analyzed the efficacy of the fifth week to begin treatment and the first year follow-up. Results: In the fifth week to begin treatment, the radical treatment group of children with serum ferritin (SF) level was （38.14±18.43） g/L,significantly higher than those children in control group （P<0.05）,with 1 year follow-up, the SF levels of the radical treatment group children was （39.18±15.92） g/L , significantly higher than the control group （22.13±12.94） g/L, the three indicators of Hb, MCV, MCH were significantly higher, the difference had statistical significance （P<0.01 or P<0.05） and the treatment process were not found serious side effects. Conclusion:There is close relationship between Hp infection and IDA, clinical treatment to children with IDA merge Hp infection should be given iron treatment and radical treatment of Hp i