简论醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的影响（资料）.docVIP

简论醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的影响（资料） 文档信息 ： 文档作为关于“医学心理学”中“药学”的参考范文，为解决如何写好实用应用文、正确编写文案格式、内容素材摘取等相关工作提供支持。正文6959字，doc格式，可编辑。质优实惠，欢迎下载！ 目录 TOC \o "1-9" \h \z \u 目录 1 正文 1 文1：简论醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的影响 1 1005-5304(2014)07-0081-04 2 1仪器、试药与动物 3 文2：醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的发展策略 5 1仪器、试药与动物 6 2方法与结果 6 参考文摘引言： 11 原创性声明（模板） 12 文章致谢（模板） 13 正文 简论醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的影响（资料） 文1：简论醋蒸对南五味子木脂素类成分在大鼠体内药代动力学的影响 DOI：/-.024 1005-5304(2014)07-0081-04 Effects of Steaming Orange Magnoliavine Fruit with Vinegar on Pharmacokinetics in RatsDENG Chong1， ZHENG Jie2， DONG Yuan-yuan1， SONG Xiao-mei1 ( of Pharmacy， Shaanxi College of TCM， Xianyang 712046， China； Hospital in Hanzhong City， Hanzhong 723000， China) Abstract：Objective To study the effects of steaming Orange Magnoliavine Fruit with vinegar on the lignan metabolism in rats. Methods The rats were fed with same amount of extracts：Orange Magnoliavine Fruit before and after steaming processing with vinegar. Then plasma samples were collected at different times and determined contents of schisantherin A and deoxyschizandrin by HPLC to draw drug concentration in blood-time curve. The pharmacokinetic paramete were calculated with analysis software. Results Pharmacokinetic model of schisantherin A and deoxyschizandrin in rats accorded with one compartment model. Plasma concentration in rats under the condition of Orange Magnoliavine Fruit samples before and after steaming processing with vinegar was：Tmax of schisantherin A was determined with (±)， (±)h respectively， Cmax with (±)， (±)μg/mL respectively， T1/2 with (±)， (±)h respectively. Tmax of deoxyschizandrin was determined with (±)， (±)h respectively， Cmax with (±)， (±)μg/mL， T1/2 with (±)， (±)h. Orange Magnoliavine Fruit before and after steaming processing with vinegar exhibited differences in pharmacokinetic paramete in rats. Conclusion The pharmacokinetic paramete of schisantherin A and deoxyschizandrin showed that the steaming processing with vinegar