静息fMRI及对癫痫的应用研究.ppt

. 静息态fMRI及对癫痫的应用研究 描绘颞叶癫痫网络 Tae et al., Neuroimage, 2005 xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 描绘颞叶癫痫网络 Tae et al., Neuroimage, 2005 ALFF xx科 Interictal Ictal Dept. of Med. Img., NJ JinLing Hos. xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 结果和讨论3 ALFF和IEDs的关系(from EEG) ? 6 patients who had undergone simultaneous EEG Patient 1 Patient 2 …… Patient 5 Patient 6 1000 TRs 10 segments in each session 静息态fMRI及对癫痫的应用研究 ALFF VS IEDs (from EEG) ? ALFF value was calculated in each segment ? ALFF values were correlated with the IED numbers Pearson correlation analysis ALFF xx科 IED number Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 结果和讨论3 ? ALFF与IEDs次数呈明显相关的脑区 xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 结果和讨论4 癫痫活动的定侧 ROI法分析 ? 双侧内侧颞叶内的 ALFF平均值 ? 左-右/左+右 静息态fMRI及对癫痫的应用研究 癫痫活动的定侧 结果和讨论4 ? 比较计算半球间的ALFF不同 = xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 结果和讨论4 ALFF 在mTLE脑中的不对称 左侧mTLE 右侧mTLE Ipsilateral hippocampus xx科 Ipsilateral thalamus Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 Hemispheric asymmetry in the healthy controls ? The physiological asymmetry in the controls should be taken account into xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 = mTLE = = Controls xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 Excluding the possible effect of the physiological asymmetry xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 结果和讨论5 单例个体分析—实际临床指 导意义 ? 2-sample t-test performed by using SPM ? 1 patient VS 27 Controls xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 Case 1 left mTLE xx科 Dept. of Med. Img., NJ JinLing Hos. 静息态fMRI及对癫痫的应用研究 Case 2