重庆大学《病理学》课件-第4章Inflammation.pptx

Chapter 4. Inflammation Section 1. Introduction重庆大学《病理学》 一 . Definition: 1. Inflammation: a defensive reaction in living tissue with vascular system to injurious stimuli.2. Reaction of BVs is the central link limiting and killing injured F eliminating and absorbing necrotic T3. The inflammatory responses is closely interviewed with the process of repair 4. Significance(1). Beneficial : without inflammation Infections would go unchecked injured organs might remain permanent wound would never heal (2). Harmful : hypersensitive reactions to drugs, toxins fibrinous pericarditis →constrictive pericarditis fibrous repair → intestinal obstruction 二 . Causes and classification(一) Causes1. Biologic factors:Bac,Virus ,fungi ,parasites →the most common2. Chemical factors Exogenous : drugs, acid Endogenous :3. Physical agents: trauma , burn 4. Tissue necrosis5. Allergic reaction:GN , TB (二) Clinical types1. Peracute inflammation(1) sudden onset, lasting for hours or a few days(2) lesion: degeneration, necrosis, exudation2. Acute inflammation(1) relatively short duration, lasting for a few days(2) lesions: degeneration, necrosis, exudation: neutrophils infiltration 3. Chronic inflammation(1) lasting longer duration for a few months or years(2) Lesions proliferation LC ,PC, Monocyte infiltration4. Subacute inflammation(1) between acute and chronic inflammation derived from acute inflammation 三 . Basic pathologic changes1. Alteration: Degeneration ,necrosis of local tissue cells Parenchymal C cellular swelling fatty change coagulative , liquefactive necrosis Mesenchymal C mucoid change amyloid change