急性肾损伤的分子机制和治疗策略.docxVIP

急性肾损伤的分子机制和治疗策略 急性肾损伤的分子机制和治疗策略摘要：急性肾损伤是一种常见病，仍然是困扰医生的严重病症之一。本文主要描述了急性肾损伤的分子机制和治疗策略。 分子机制方面，重点介绍了炎症反应、氧化应激和凋亡等引起急性肾损伤的分子机制。治疗策略方面，主要从非特异性干预手段、特异性治疗以及细胞治疗等几个方面探讨了治疗急性肾损伤的策略。关键词：急性肾损伤、分子机制、治疗策略、非特异性干预手段、特异性治疗、细胞治疗Acute Kidney Injury: Molecular Mechanisms and Treatment StrategiesAbstract:Acute kidney injury is a common disease and still one of the serious diseases that plaguing doctors. This article mainly describes the molecular mechanisms and treatment strategies of acute kidney injury. In terms of molecular mechanisms, this review focuses on inflammation, oxidative stress, and apoptosis; that caused acute kidney injury. On the treatment strategies, mainly discussed the strategies for treating acute kidney injury from non-specific intervention measures, specific treatment, and cell therapy.Keywords:Acute kidney injury, molecular mechanisms, treatment strategies, non-specific intervention measures, specific treatment, cell therapyIntroductionAcute kidney injury (AKI) is a common and severe clinical syndrome that leads to high morbidity and mortality in hospitalized patients. The incidence of AKI has been increasing over the past decade due to the aging population, the increasing incidence of diabetes, and hypertension. AKI can be caused by a wide variety of causes, including sepsis, ischemia/reperfusion injury, nephrotoxic agents, and hypovolemia. Despite advances in medical care and the use of supportive therapies, the mortality rate among patients with AKI remains high.Molecular Mechanisms of AKIInflammationInflammation is one of the major causes of AKI, characterized by the infiltration of inflammatory cells and the production of inflammatory cytokines. Inflammatory cells produce cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), which can increase oxidative stress and reduce blood flow to the kidneys. This response leads to tubular cell injury, apoptosis, and ultimately renal injury.Oxidative StressOxida