长链非编码RNA在免疫系统调节中的作用.docxVIP

长链非编码RNA在免疫系统调节中的作用 AbstractLong non-coding RNAs (lncRNAs) have recently emerged as key players in the regulation of immune response and are involved in diverse cellular processes. This review aims to provide an overview of the functions of lncRNAs in immunoregulation, including their roles in inflammatory response, immune cell differentiation and proliferation, and immune checkpoint regulation. Additionally, we discuss how lncRNAs may be involved in the development of immune-related diseases, such as autoimmune disorders and cancer. Improved understanding of the roles of lncRNAs in immune regulation will provide new opportunities to develop targeted therapies for a range of immune-related diseases.Keywords: Long non-coding RNA, Immunoregulation, Inflammatory response, Immune cell differentiation and proliferation, Immune checkpoint regulation, Autoimmune disorders, Cancer.摘要近年来，长链非编码RNA(lncRNA) 在免疫反应调节中已被证明是重要的调节因子，涉及多种细胞过程。本综述旨在概述lncRNA在免疫调节中的功能，包括它们在炎症反应、免疫细胞分化增殖和免疫检查点调节中的作用。此外，本文还讨论了lncRNA如何参与免疫相关疾病的发展，如自身免疫性疾病和癌症。深入了解lncRNA在免疫调节中的作用将为开发针对各种免疫相关疾病的有针对性治疗提供新机会。关键词：长链非编码RNA、免疫调节、炎症反应、免疫细胞分化增殖、免疫检查点调节、自身免疫性疾病、癌症。IntroductionLong non-coding RNA (lncRNA) is a class of non-coding RNAs with a length of more than 200 nucleotides. They are responsible for regulating various biological processes by acting as transcriptional and post-transcriptional regulators, epigenetic modulators, and scaffolds for protein complexes. In recent years, emerging evidence has identified lncRNAs as critical regulators of immune cell phenotype and function, playing vital roles in immune system development, activation and suppression, as well as immune-related pathologies.LncRNAs in Inflammatory ResponseInflammatory response is a critical component of the innate immune system, which is essential for host defense against pathogen infection and tissue damage. Dysregulation of inflammatory response can lead to chronic inflammatory diseases, such as rheumatoid arthritis and infla