细胞Cell senescence.ppt

Cell senescence and aging 刘招舰 细胞生物学研究所 Contents Introduction Characteristics of senescent cells Theories of Cell senescence (Mechanism) Cell senescence and Cancer Cell senescence cardiovascular disease Cell senescence and longevity How to study Cell senescence 1 Whether you want to extends lifespan or not? Overpopulation is a problem 2 The world is growing older. Global Aging: The New New Thing 3 Diseases of Aging Cancer Cardiovascular disease Cerebrovascular disease Arthritis Osteoporosis Neurodegenerative disease Diabetes (Type II) 4 Aging is a Very General Phenomenon! The basic concepts and definition Ageing aging senescence senescence The word senescence is derived from the Latin word senex, meaning "old man" or "old age" or "advanced in age". Ageing or aging (American English) is a syndrome of changes that are deleterious, progressive, universal characteristics and thus far irreversible. Ageing of the whole organism Ageing is generally characterized by the declining ability to respond to stress, increasing homeostatic imbalance and increased risk of aging associated diseases. Cellular senescence Cellular senescence The phenomenon where normal diploid differentiated cells lose the ability to divide, normally after about 50 cell divisions in vitro, some cells become senescent before because of DNA double strand breaks, toxins etc. This phenomenon is also known as "replicative senescence", the Hayflick limit. a irreversible proliferative arrest b remained viable for many weeks Cellular senescence Senescent cells, as they are called, are no longer capable of dividing yet remain metabolically active. cellular senescence is sometimes termed cellular ageing or replicative senescence. Contents Introduction Characteristics of senescent cells Theories of Cell senescence (Mechanism) Cell senescence and Cancer Cell senescence cardiovascular disease Cell senescence and longevity How to study Cell senescence II Characteris