OMA临床实践声明：抗肥胖药物和研究药物.docx

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OMA临床实践声明：抗肥胖药物和研究药物.docx

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TitleAntiObesityMedicationsandInvestigationalAgentsAnObesityMedicineAssociationClinicalPracticeStatement2022AbstractThisAntiObesityMedicationsandInvestigationalAgentsAnObesityMedicineAssociationClinicalPracticeSta

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ObesityPillars2(2022)100018

Anti-ObesityMedicationsandInvestigationalAgents:AnObesityMedicineAssociation(OMA)ClinicalPracticeStatement(CPS)2022

HaroldE.Baysa,*,AngelaFitchb,SandraChristensenc,KarliBurridged,e,JustinTondtf

LouisvilleMetabolicandAtherosclerosisResearchCenter,UniversityofLouisvilleSchoolofMedicine,3288IllinoisAvenue,Louisville,KY,40213,USA

AssistantProfessorofMedicineHarvardMedicalSchool,Co-DirectorMassachusettsGeneralHospitalWeightCenter,Boston,MA,USA

IntegrativeMedicalWeightManagement,2611NE125thSt,Suite100B,Seattle,WA,98125,USA

EnaraHealth,16501106thCourt,OrlandPark,IL,60467,USA

GainingHealth,528PennsylvaniaAve#708,GlenEllyn,IL,60137,USA

DepartmentofFamilyandCommunityMedicine,EasternVirginiaMedicalSchool,P.O.Box1980,Norfolk,VA,23501,USA

ARTICLEINFO

ABSTRACT

Keywords:

Anti-obesitymedications

Investigationalagents

Obesity

Semaglutide

Tirzepatide

Background:This“Anti-ObesityMedicationsandInvestigationalAgents:AnObesityMedicineAssociationClinicalPracticeStatement2022”isintendedtoprovidecliniciansanoverviewofFoodandDrugAdministration(FDA)approvedanti-obesitymedicationsandinvestigationalanti-obesityagentsindevelopment.

Methods:Thescienti?cinformationforthisClinicalPracticeStatement(CPS)isbaseduponpublishedscienti?ccitations,clinicalperspectivesofOMAauthors,andpeerreviewbytheObesityMedicineAssociationleadership.

Results:ThisCPSdescribespharmacokineticprinciplesapplicabletothosewithobesity,anddiscussestheef?cacyandsafetyofanti-obesitymedications[e.g.,phentermine,semaglutide,liraglutide,phentermine/topiramate,naltrexone/bupropion,andorlistat,aswellasnon-systemicsuperabsorbentoralhydrogelparticles(whichistechnicallyclassi?edasamedicaldevice)].Othermedicationsdiscussedincludesetmelanotide,metreleptin,andl