enzyme-catalyzed processes pharmaceutical industry制药工业中酶催化过程.pdfVIP

AppliedCatalysisA:General221(2001)145–158

Enzyme-catalyzedprocessesinpharmaceuticalindustry

J.PeterRasora,∗,EdgarVossb

aRocheAppliedScience,GlobalMarketing,RocheDiagnosticsGmbH,WerkPenzberg,Nonnenwald2,82377Penzberg,Germany

bRochePharmaceuticals,HighPressureandCatalysisLaboratory,RocheDiagnosticsGmbH,WerkPenzberg,

Nonnenwald2,82377Penzberg,Germany

Biocatalysisisenjoyinganreasinginterestnotonlyinacademia,butalsoinindustry.Ithasbeenthetopicofseveral

excellentreviewsorbooks[BornscheuerandKaszlauskas,HydrolasesinOrganicSynthesis—Regio-andStereoselective

Biotransformations,Wiley-VCH,Weinheim,1999;H.-J.Rehm,G.Reed,A.Pühler,P.Stadler(Eds.),Biotechnology,Bio-

transformations,Vol.8,Wiley-VCH,Weinheim,1998;Faber,Biotransformation,OrganicChemistry,Berlin,1996;

K.Drauz,H.Waldmann,(Eds.),EnzymeCatalysisinOrganicSynthesis,VCHVerlagsgesellschaftmbH,Weinheim,1995;

WongandWhitesides,EnzymesinSyntheticOrganicChemistry,TetrahedronOrganicChemistry,Vol.12,Pergamon,Oxford,

1994;Sheldon,Chirotechnology,MarcelDekker,NewYork,1993;Chem.Today13(1995)9;DrugDiscoveryToday2(1997)

513;Bioorg.Med.Chem.7(1999)2253;J.Chem.Soc.,PerkinTrans.1(1999)1;U.T.Bornscheuer,in:Biotechnology—

BiotransformationsII,Vol.8b,Wiley-VCH,Weinheim,2000pp.277–294.][1–11].Aimofthisarticleistopresentrecent

developmentsofbiocatalysisinthepharmaceuticalindustryinamoredidacticalmanner.Anoutlookonfutureaspectsof

biocatalysiswillreflecttheauthorsopinion.Wewilldiscussthefundamentalstrengthofbiocatalysisbutalsosomecommonly

heldpre-conceptions,whichwebelievearesuperficial.©2001ElsevierSci