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?Multi-detector spiral CT study of the relationshipsbetween pulmonary ground-glass nodules and blood vessels Eur Radiol (2013) 23:3271–3277 Abstract Objective : To investigate the relationships between pulmo-nary ground-glass nodules (GGN) and blood vessels and their diagnostic values in differentiating GGNs. Conclusion : Different GGNs have different relationships with vessels. Understanding and recognising characteristic GGN-vessel relationships may help identify which GGNs are more likely to be malignant. Key Points Multi-detector CT offers new information about ground- glass nodules. Different types of ground-glass nodules have different relationships with vessels. This may help identify which ground-glass nodules are likely to be malignant. Introduction With the extensive acceptance of low-dose multi-detector spiral CT in lung cancer screening , the number of detected GGNs or focal ground-glass opacities (fGGOs) has dramatically increased. GGNs can result from neoplasms, such as pulmonary adenocarcinoma, or benign diseases, such as focal fibrosis, inflammation or alveolar haemorrhage. In addition, pre-invasive abnormalities, including atypical adenomatous hyperplasia (AAH) and adenocarcinoma in situ (AIS). It has been reported that the proportion of malignancy in GGNs is higher than in solid pulmonary nodules (SPNs) and the majority of malignant GGNs are adenocarcinoma . Due to imaging resemblance, however, it is extremely challenging to differentiate malignant GGNs from the aforementioned benign counterparts. ? Accurate differential diagnosis of GGNs will assist physicians to make treatment decisions and improve treatment outcomes and prognosis. Several investigators have suggested that analysis of relationships between SPNs and surrounding vessels can help predict the likelihood of malignancy in such nodules. The relationship between GGNs and blood vessels remains unknown. Whether this relationship can be utilised to facilitat
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