器官发育的分子机制.ppt

器官发育的分子机制 福建师范大学 福建师范大学生命科学学院 胡雪峰 bioxfh@fjnu.edu.cn Most organs form via epithelial-mesenchyme interactions and share common early morphological features 哺乳动物的牙齿发育过程 de de de de de dm dm dm dm dm 牙板期 蕾状期 帽状期 钟状早期 钟状晚期 Early Mouse Molar Development 哺乳动物牙齿的发育过程 成牙釉质细胞 成牙本质细胞 牙釉质 牙本质 E11.5 6W E13.5 8W Chai Y,Slavkin HC.2003 E14.5 11W E16.5 15W E18.5 18W Numerous Genes Are Involved In Tooth Development Chai and Slavkin, (2003) Micros Res. Tech. * Molar epi. Molar mes. 2nd arch epi. 2nd arch mes. Tissue Recombination Tooth Tooth Molar epi. prior to E12 Molar Mes. After E12 Odontogenic Potential Shifts Between Tissue Layers 1). Dental epithelium prior to E12 contains odontogenic potential 2). Dental mesenchyme after E12 acquires odontogenic potential. Molar tooth germ 2nd branchial arch * * * * * * * Generation of Tooth From Cultured Cells in vitro A model for future tooth replacement therapy