老年2型糖尿病应用胰岛素泵有效性和安全性.ppt

胰岛素强化治疗的临床应用 马建华吴锦丹 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  UKPDS: Cardiovascular Risk Increases With Increasing Glyceamia Adapted from Stratton IM et al. BMJ. 2000; 321: 405-412 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  达到并保持HbA1c达标 FPG和PPG的作用 00 ■空腹血糖(FPG 30% 餐后血糖(PPG) 趣6070%60%55%50% 70% 30%40%45%50% >10.210.29.39.28.58.4-7.3<7.3 A1C范围(% Monnier L, et al. Diabete Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  仝新的2型糖尿病胰岛素治疗理念 400 血300 2型糖尿病患者 糖 200 正常人 6:0010:0014:0018:0022:0002:000600 天中的时间 Polonsky KS, et al, N Engl J Med. 1988 May 12: 318(19): 1231-9 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  不同胰岛素的药效动力学 1型糖尿病 胰岛素皮下注射 20例 NPH 特慢效胰岛素锌悬液 通过胰岛素泵12§ 续皮下胰岛素输注 其精肤岛素 12 时间(小时) Adapted with permission from Lepore M et al. Diabetes, 2000: 49: 21422-2148 Evaluauon onr. ch Asposeslides for NET 4o dient P alveton o Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  胰岛素强化治疗 CSIl (continue subcutaneous insulin injection MDI(multiple daily injection Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose Pty L  胰岛素泵( nsulin Pump) m持续皮下胰岛素输注(cS) 胰岛素泵能模拟正常胰腺的胰岛素分泌模式,持续24小时向 患者体内输入微量胰岛素 胰岛素泵两种输注方式 基础输注率( Basal rate) 控制两餐间和夜间的血糖的基础胰岛素 餐前负荷量( Bolus) 控制餐后血糖和高血糖校正所需的胰岛素量 Evaluauon onr. ch Asposeslides for NET 4o dient P Evaluation only. Created with Aspose Slides for NET 4.0 dient Profilo 71 Copyright 2004-2017Aspose P