围产期孕妇生殖道B族链球菌感染与耐药性分析-现代临床医学.doc

2015-10-11 完成编辑加工 2016-06 2016-06-07 2016-6-21，主任加工 围生期孕妇生殖道B族链球菌感染与耐药性分析 刘 丽1，杨文东2 （1. 东营市东营区妇幼保健计划生育服务中心，山东 东营 257091； 2.东营市利津县第二人民医院，山东 东营 257447） [摘要]目的：分析围生期孕妇生殖道B族链球菌(GBS)的感染与耐药性，为临床医师制定有效的预防和治疗措施提供依据。方法：对795例围生期孕妇生殖道分泌物进行GBS培养鉴定与药敏试验，分析实验结果。结果：795例孕妇中共检出GBS携带者256例，带菌率32.20%。＜30岁组(28.88%)与≥30岁组(42.35%)的带菌率具显著性差异（P＜0.01）。GBS阳性者与阴性者的临床症状发生率(18.75%，7.98%)也具有显著性差异（P＜0.01）；万古霉素、利奈唑胺、青霉素等10种抗菌药物的耐药率为0%～58.1%，D-抑菌圈试验阳性率为23.9%。结论：山东东营地区围生期孕妇GBS带菌率较高，以高龄者易于感染，感染GBS者对万古霉素、利奈唑胺、青霉素、氨苄西林、头孢曲松及呋喃妥因敏感率高（89.8%～100%）。 [关键词]B族链球菌；围生期孕妇；带菌率；药敏试验 [中图分类号]R714.7；R446.5 [文献标识码]A DOI:10.11851/j.issn.1673-1557.2016.04.0 Group B Streptococcus Infection in Genital Tract of Perinatal Pregnant Women and Its Drug Resistance Analysis LIU Li 1, YANG Wendong2 (1.Maternal and Child Health Care of Family Planning Service Center of Dongying District, Shandong Dongying 257091, China; 2. Second People’s Hospital of Lijin County, Shandong Dongying 257447, China) [Abstract]Objective: To analyze the group B Streptococcus (GBS) infection in genital tract of perinatal pregnant women and its drug resistance, and to provide a reference for clinicians to treating and preventing this infection. Methods: From January 2013 to February 2015, the vaginal secretions were sampled from 795 perinatal pregnant women for culture identification of GBS; the final results were statistically analyzed. Results: In 795 pregnant women, there were 256 GBS carriers; the germ-carrying rate was 32.2%. There was a significant difference in the germ-carrying rate between ＜ 30 years old group (28.9%) and ≥ 30 years old group (42.3%)(χ２=19.095, P＜0.01).The incidence of clinical symptoms between GBS negative cases and GBS positive ones (18.8%, 8.0%) also had statistical difference（χ２=39.514，P＜0.01）. The antimicrobial resistant rates of ten kinds of antibacterial drugs (vancomycin, linezolid，penicillin，ampicillin，ceftriaxone, nitrofurantoin，levofloxacin, clindamycin，erythromycin and tetracycline) for treating GBS was 0