【持续性肾脏替代治疗CRRT英文ppt课件】Treatment Related Factors.ppt

Treatment Related Factors;Little et al, AJKD, Vol 36, pp 1135-1139, 2000;A- IJ catheter with no recirculation; B- 20 cm FE catheter assumed to haveAR of 0% at 150 mL/min, 8.5% at 250 mL/min and 17% at 350 mL/min; C-15 cm FE catheter assumed to have AR of 5% at 150 mL/min, 20% at 250mL/min and 30% at 350 mL/min(iHD treatments are modelled under the following conditions; duration 240 mins, dialysate flow 500 mL/min, hemodialyzer mass transfer coefficient 911 mL/min, V 40 L, nPCR 0.8 g/kg/day);Treatment Related Factors;Marshall and Golper, UpToDate, “Sustained Low-Efficiency Dialysis”;Treatment Related Factors;;Treatment Related Factors;Treatment Related Factors;Treatment Related Factors;Treatment Related Factors;Overview;Dose-Outcome DataCRRT;;Table I – Clinical Diagnosis of study patients;;;;;;;;;Dose-Outcome Data (CRRT);Dose-Outcome DataiHD;;;;;;;;;;;;;Dose-Outcome Data (iHD);;Phu et al.;CAPD provided unsatisfactory control of cidosis, longer duration of ARF, poorer survival;Overview;CRRT Prescription;CRRT Prescription;iHD Prescription;iHD Prescription;PD Prescription;Dose and Therapy Choice;Is there an expression of acuteRRT dose that will allow us toreconcile these differentrecommendations for iHD andCRRT?;Standard Kt/V (stdKt/V)Units: week-1;;;stdKt/V;Corrected Equivalent RenalUrea Clearance (EKRc)Units: mL/min;= G/TAC or J/TAC;A comparison of BUN time-concentration profiles between twointermittent hemodialysis regimens delivering a cEKR of 24 ml/min. Thesolid line reflects solute removal over 3 treatments per week, the dottedsolute removal over 7 treatments per week.;EKRc (1st Generation);; ;;;EKRjc (2nd Generation);EKRjc (2nd Generation); ; ;;;/; ;;/ct/show/NC;How should one prescribe and dose acute RRT to optimize patient outcomes?