皮肤淋巴瘤--课件.pptxVIP

皮肤淋巴瘤 ppt课件 1 introduction ¡ The term “primary cutaneous lymphoma” refers to cutaneous T-cell lymphomas (CTCLs) and cutaneous B-cell lymphomas (CBCLs) that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. Primary cutaneous lymphomas often have a completely different clinical behavior and prognosis from histologically similar systemic lymphomas, which may involve the skin secondarily, and therefore require different types of treatment. ppt课件 2 ¡Primary cutaneous lymphomas are currently classified by the European Organization for Research and Treatment of Cancer (EORTC) classification or the World Health Organization (WHO) classification, but both systems have shortcomings. During recent consensus meetings representatives of both systems reached agreement on a new classification, which is now called the WHO-EORTC classification. ppt课件 3 ppt课件 4 ppt课件 5 ppt课件 6 蕈样霉菌病(MF) 蕈样霉菌病是一种常见嗜表皮性的皮肤T细胞淋巴瘤( CTCL)，特点是增生的小至中等大小的T淋巴细胞，有 “脑回样”的核。 MF是最常见的皮肤T细胞淋巴瘤，约占 所有皮肤原发性淋巴瘤的50%。 Mycosis Fungoides (MF) MF is a commonly epidermotropic CTCL characterized by a proliferation of small- to mediumsized T lymphocytes with cerebriform nuclei . ppt课件 7 临床特征： MF多发在成人，有惰性的临床病程、进展缓慢，从 斑块到浸润的斑块最后到肿瘤经时数年，有时可达 十几年。在部分病人，淋巴结和内脏器官可能会在 疾病的晚期被累及。肿块期的MF病人可特征性地同 时出现斑点、斑块和瘤块，后者多出现溃疡。 ppt课件 8 Clinical features MF has an indolent clinical course with slow progression over years or sometimes decades, from patches to more infiltrated plaques and eventually to tumors . ppt课件