Meta分析SCI论文报告规范及写作技巧完整课件.pptx

Meta分析SCI论文报告规范及写作技巧;PRISMA声明;;一、标题;;[例 3] Perceived job insecurity as a risk factor for incident coronary heart disease： systematic reviewand meta-analysis 此题目包含了 I( perceived job insecurity)和 O(incident coronary heart disease)。 从上面几例可以看出，一个合格的系统评价/ Meta分析题目至少应包括两个最基本的，也是必备的信息，即I干预和O结局（或者P人群）。 ;条目2 结构式摘要——提供结构式的摘要包括：背景、目的、资料来源、纳入研究标准、研究对象和干预措施、研究评价和综合方法、结果、局限性、结论和主要发现、系统评价的资助、系统评价的注册号;完全型结构式摘要;Abstract Background:Adenomatous polyposis coli (APC) is an important tumor suppressor gene in breast cancer. However, there were inconsistent conclusions in the association between APC promoter methylation and breast cancer. Hence, we conducted a meta-analysis to quantitatively assess the clinicopathological significance and diagnosis role of APC methylation in breast cancer. Methods：We conducted a meta-analysis to quantitatively evaluate the diagnostic value of APC promoter methylation in breast cancer and the associations between APC promoter methylation and incidence or clinicopathological characteristics of breast cancer. Odd ratios (OR) and corresponding 95% confidence intervals (95% CI) were used to assess such association. The area under the summary ROC curve (AUC) was used to assess the diagnostic value. Results:In total, 3172 samples from 29 studies were performed in this study. The odds ratio (OR) of APC methylation was 5.92 (95% CI = 3.16–11.07) in breast cancer cases compared to controls,. The APC promoter methylation was associated with cancer stage (OR = 0.47, 95% CI = 0.28–0.80, P = 0.006), lymph node metastases (OR = 0.55, 95% CI = 0.36–0.84, P = 0.005) and ER status (OR = 1.34, 95% CI = 1.03–1.73, P = 0.003) in breast cancer. Furthermore, the sensitivity and specificity for all included studies were 0.444 (95% CI: 0.321–0.575, P < 0.0001) and 0.976 (95% CI: 0.916–0.993, P < 0.0001), respectively. Conclusions: APC promoter methylation was closely associated with breast cancer, and it could be used as a biomarker for diagnosis, treatment and prognosis of brea